Dydrogesterone Mode of Action
WOMEN'S HEALTH
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What makes duphaston so effective

WHAT MAKES
DUPHASTON®
SO EFFECTIVE

THE ENHANCED PROGESTOGEN THAT IS CLINICALLY
PROVEN TO TREAT PROGESTERONE DEFICIENCIES1-4

Duphaston® (dydrogesterone 10mg) is derived from progesterone sourced from wild yam plants. The use of light technology during the production of dydrogesterone shaped the progesterone molecule into a retroprogesterone which enhances the pharmacology, resulting in the following benefits:

Dydrogesterone
  • Increased bioavailability
    (~5.6 times higher than
    progesterone) for oral intake1
  • High selectivity for
    progesterone receptors 3
 

DUPHASTON® IS A POTENT PROGESTERONE RECEPTOR AGONIST5-7

Differences in the structure of dydrogesterone and progesterone influence potency and potential side effect profile5-7

BIOLOGICAL ACTIVITY PROGESTERONE DUPHASTON®
Progestogenic + +
Anti-gonadotropic + -
info_iconNO INHIBITION OF OVULATION WITH DUPHASTON® AT THERAPEUTIC DOSES5,6
Anti-estrogenic + +
Estrogenic - -
Androgenic - -
Anti-androgenic +/- +/-
info_iconANTI-ANDROGENIC ACTIVITY7
Duphaston® has less pronounced anti-androgenic pre-receptor effects than progesterone
Glucocorticoid + -
info_iconNO GLUCOCORTICOID ACTIVITY WITH DUPHASTON®6
Anti-mineralocorticoid + +/-

+ effective; +/- weekly effective; - not effective

RECOMMENDED

women's needs

Duphaston® your trusted partner for women’s needs

Please see accompanying

PRESCRIBING INFORMATION

 

1. Stanczyk FZ, Hapgood JP, Winer S, et al. Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects. Endocr Rev. 2013 Apr;34(2):171-208.

2. Paulson RJ, Collins MG, Yankov VI. Progesterone Pharmacokinetics and Pharmacodynamics With 3 Dosages and 2 Regimens of an Effervescent Micronized Progesterone Vaginal Insert. J Clin Endocrinol Metab. 2014;99(11):4241–4249.

3. Schindler AE, Campagnoli C, Druckmann R, et al. Classification and pharmacology of progestins. Maturitas. 2008;61(1–2):171–180.

4. Podzolkova N, Tatarchuk T, Doshchanova A, et al. Dydrogesterone treatment for menstrual-cycle regularization in routine clinical practice: a multicenter observational study. Gynecol Endocrinol 2016;32(3):246–249.

5. Kuhl H. Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric. 2005;8(Suppl 1):3–63.

6. Schindler AE, Campagnoli C, Druckmann R, et al. Classification and pharmacology of progestins. Maturitas. 2008;61(1–2):171–180.

7. Rizner TL, Brožič P, Doucette C, et al. Selectivity and potency of the retroprogesterone dydrogesterone in vitro. Steriods. 2011;76(6):607–615.

 

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