Dydrogesterone Mode of Action
WOMEN'S HEALTH
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THE ENHANCED PROGESTOGEN THAT IS CLINICALLY
PROVEN TO TREAT PROGESTERONE DEFICIENCIES1-4

Duphaston® (dydrogesterone 10mg) is derived from progesterone sourced from wild yam plants. The use of light technology during the production of dydrogesterone shaped the progesterone molecule into a retroprogesterone which enhances the pharmacology, resulting in the following benefits:

Dydrogesterone
  • Increased bioavailability
    (~5.6 times higher than
    progesterone) for oral intake1
  • High selectivity for
    progesterone receptors 3
 

DUPHASTON® IS A POTENT PROGESTERONE RECEPTOR AGONIST5-7

Differences in the structure of dydrogesterone and progesterone influence potency and potential side effect profile5-7

BIOLOGICAL ACTIVITY PROGESTERONE DUPHASTON®
Progestogenic + +
Anti-gonadotropic + -
info_iconNO INHIBITION OF OVULATION WITH DUPHASTON® AT THERAPEUTIC DOSES5,6
Anti-estrogenic + +
Estrogenic - -
Androgenic - -
Anti-androgenic +/- +/-
info_iconANTI-ANDROGENIC ACTIVITY7
Duphaston® has less pronounced anti-androgenic pre-receptor effects than progesterone
Glucocorticoid + -
info_iconNO GLUCOCORTICOID ACTIVITY WITH DUPHASTON®6
Anti-mineralocorticoid + +/-

+ effective; +/- weekly effective; - not effective

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