Duphaston® (dydrogesterone 10mg) is derived from progesterone sourced from wild yam plants. The use of light technology during the production of dydrogesterone shaped the progesterone molecule into a retroprogesterone which enhances the pharmacology, resulting in the following benefits:
Differences in the structure of dydrogesterone and progesterone influence potency and potential side effect profile5-7
BIOLOGICAL ACTIVITY | PROGESTERONE | DUPHASTON® |
---|---|---|
Progestogenic | + | + |
Anti-gonadotropic | + | -![]() |
Anti-estrogenic | + | + |
Estrogenic | - | - |
Androgenic | - | - |
Anti-androgenic | +/- | +/-![]() Duphaston® has less pronounced anti-androgenic pre-receptor effects than progesterone |
Glucocorticoid | + | -![]() |
Anti-mineralocorticoid | + | +/- |
+ effective; +/- weekly effective; - not effective
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