Dosage
WOMEN'S HEALTH
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DOSAGES,TREATMENT SCHEDULE AND DURATION OF TREATMENT MAY BE ADAPTED TO THE SEVERITYOF THE DYSFUNCTION AND THE CLINICAL RESPONSE.

  • Dysmenorrhea1
  • 10 mg dydrogesterone twice daily from day 5 to day 25 of the menstrual cycle.

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  • Endometriosis1
  • 10 mg dydrogesterone two or three times per day from day 5 to day 25 of the cycle or continuously.

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  • Dysfunctional uterine bleeding:1
  • Bleeding is triggered with 10 mg twice daily for 5 to 7 days, combined with an estrogen.Several days after the end of this treatment, withdrawl bleeding will occur. Subsequent heavier bleeding can be prevented by prescribing 10 mg daily prophylactically from the 11th to the 25th day of the cycle.

    In cases of cystic metropathia haemorrhagica, 10 mg daily are given from the 11th to the 25th day of the cycle.

    In some cases it may be necessary to give an estrogen during the first half of the cycle. Several days after stopping this treatment, withdrawal bleeding will occur. This treatment should preferably be continued for several cycles.

  • Secondary amenorrhea:1
  • An estrogen once daily from day 1 to day 25 of the cycle, together with 10 mg dydrogesterone twice daily from day 11 to day 25 of the cycle.

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  • Pre-menstrual syndrome:1
  • 10 mg twice daily from day 11 to day 25 of the cycle.

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  • Irregular cycles:1
  • 10 mg twice daily from day 11 to day 25 of the cycle.

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  • Threatened abortion, associated with proven progesterone deficiency1
  • 40 mg at once, then 10 mg every night hours until symptoms remit.

  • Habitual abortion, associated with proven progesterone deficiency1
  • 10 mg twice daily until the twentieth week of pregnancy.

  • Infertility due to luteral sufficiency:1
  • 10 mg daily from day 14 to day 25 of the cycle. Treatment should be maintained for atleast six consecutive cycles. It is advisable to continue this treatment for the first few months of pregnancy as described under 'Habitual abortion'.

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Duphaston® is not recommented for use in children below age 18 due to insufficient data on safety and efficacy.

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